HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 2-(Hexahydro-1H-azepin-1-yl)-2-methylpropanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 1-(Dimethylamino)cyclopentanecarbonitrile | HCID 10773049 | — |
| Reactant | 1H-Azepine, hexahydro-, hydrochloride | HCID 11971665 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(Hexahydro-1H-azepin-1-yl)-2-methylpropanenitrile | HCID 16448245 | 80% |
Reaction Steps
The title compound (6.6 g: 80%) was prepared from homopiperidine hydrochloride (6.7 g; 49 mmol), acetone (3.67 ml; 50 mmol), and potassium cyanide (3.25 g; 50 mmol) in water (25 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ 1.43 (6H, s), 1.50-1.65 (8H, m), 2.66 (4H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745642B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-e013f3b38f9149ffa440cbfd1fb00ef4 |
| Source note | uspto-grants-2010_06 |