Chloroacetone → HCID 178441925, compound

HRID 2082058Notes

Reaction equation

[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]#[N:21])=[CH:10][CH:9]=2)[C:5]([CH2:22][CH2:23][CH2:24][CH3:25])=[N:4][N:3]=1.[Cl:26][CH2:27][C:28](=[O:30])[CH3:29]>>[Cl-:26].[CH2:27]([N+:3]1[N:4]=[C:5]([CH2:22][CH2:23][CH2:24][CH3:25])[N:6]([CH2:7][C:8]2[CH:9]=[CH:10][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]#[N:21])=[CH:12][CH:13]=2)[C:2]=1[NH2:1])[C:28]([CH3:29])=[O:30]

Participants

Reactant 2

HCID 6571Chloroacetone

HCID 100652943-amino-5-butyl-4-[(2'-cyanobiphenyl-4-yl)methyl]-4H-1,2,4-triazole

Product 1

HCID 178441925HCID 178441925, compoundYield 97%

Procedure

Reaction of 3-amino-5-butyl-4-[(2'-cyanobiphenyl-4-yl)methyl]-4H-1,2,4-triazole (from Example 1, Step D) with chloroacetone according to the procedure of Example 1, Step E, gave a 97% yield of the title compound as a yellow-brown solid, mp 221.5°-223° C.

Sources & evidence

ORD record: ord-4fbb8b05bb16468387478ef9bc5885c3
Source dataset: uspto-grants-1993_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05187179

Reaction notes

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