Ammonia → HCID 14971802, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 4,5-diphenyl-2-oxazoleacetate (10.24 g, 33 mmol) and ammonia (35 mL) was heated in a bomb at about 130° C. for about 24 hours. After evaporation of the NH3, the residue was chromatographed on a column of silica gel using EtOAc/hexanes (4:1) as eluent to give the title compound (3.21 g, 34%), mp 129°-133° C. IR (KBr) 3340, 3200, 1665 cm-1 ; 1H NMR (CDCl3) δ3.83 (2H, s, CH2CONH2), 7.27 to 7.40 (6H, m, aromatic H), 6.50 to 6.68 (4H, m, aromatic H); MS m/z 279 (MH+).

Provenance & Evidence