Potassium Carbonate → HCID 19779542, compound

Participants

Reaction Steps

To a solution of N-acetoxy-N-[3-(3-methoxyphenyl)cyclobutyl]acetamide, (34.8 mmol from above), in methanol (150 mL) was added K2CO3 (9.22 g, 69.6 mmol) and the heterogeneous mixture was stirred for 30 min. An additional portion of K2CO3 (4.50 g) was then added and the reaction was stirred an additional 30 min. It was then filtered through Celite and concentrated. The resulting residue was chromatographed (silica gel; ether) to afford 4.92 g (60% over four steps) of N-[3-(3-methoxyphenyl)cyclobutyl]-N-hydroxyacetamide as an orange oil.

Provenance & Evidence