反应详情

The equivalent amount of a 40% caustic soda solution is added, by drops, to a mixture of 300 g 4-benzoyloxy-4'-nitrobiphenyl (see Example 2) and 1500 ml ethanol; after addition, the mixture is heated under reflux for 30 min and then allowed to stand at room temperature overnight. Subsequently, the sodium salt is filtered off and dried. The free base, i.e. the hydroxy compound, is released by suspension of the sodium salt in water and acidification with half-concentrated hydrochloric acid The raw product is filtered off, washed neutral with water and recrystallized from ethanol (melting point: 204° C.); yield: 80%.

1. additionafter addition
2. temperaturethe mixture is heated
3. temperatureunder reflux for 30 min
4. filtrationSubsequently, the sodium salt is filtered off
5. customdried
6. additionThe free base, i.e. the hydroxy compound, is released by suspension of the sodium salt in water and acidification with half-concentrated hydrochloric acid The raw product
7. filtrationis filtered off
8. washwashed neutral with water
9. customrecrystallized from ethanol (melting point: 204° C.)