HCID 18612293, compound → HCID 18612289, compound

HRID 2082172Notes

Reaction equation

HRID 2082172 reaction equation
C([O:8][C@H:9]([CH2:18][O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH2:10][O:11][C:12](=[O:17])[CH2:13][CH2:14][CH2:15][Cl:16])C1C=CC=CC=1.[H][H]>C(O)(=O)C.[Pd]=O>[Cl:16][CH2:15][CH2:14][CH2:13][C:12]([O:11][CH2:10][C@@H:9]([CH2:18][O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[OH:8])=[O:17]

Participants

5

Reactant 2

HCID 18612293HCID 18612293, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18612289HCID 18612289, compound

Reagents, catalysts & solvents 2

HCID 5083724Palladium monoxideCatalystHCID 176Acetic AcidSolvent

Procedure

A solution of 0.4 g of (R)-2-O-benzyl-1-O-(4-chlorobutyryl)-3-O-octadecylglycerine in 20 ml of glacial acetic acid is treated with 0.120 g of palladium oxide and hydrogen. The catalyst is removed by filtration under suction and the filtrate is dried under reduced pressure. There is obtained (R)-1-O-(4-chlorobutyryl)-3-O-octadecylglycerine of melting point 48° C.

Workup

  1. customThe catalyst is removed by filtration under suction
  2. customthe filtrate is dried under reduced pressure

Sources & evidence

ORD record
ord-eef810297d824010aa9cdb725b1e5eb7
Source dataset
uspto-grants-1993_02
Patent number
US05187293

Reaction notes

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