Pyridine → HCID 67882225, compound

HRID 2082174Notes

Reaction equation

HRID 2082174 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][C@@H:9]([CH2:15][O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[O:10][C:11](=[O:14])[NH:12][CH3:13])=[O:6].[N:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[Cl-:1].[CH3:13][NH:12][C:11]([O:10][C@H:9]([CH2:15][O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH2:8][O:7][C:5]([CH2:4][CH2:3][CH2:2][N+:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:6])=[O:14]

Participants

3

Reactant 2

HCID 1049PyridineHCID 18612288HCID 18612288, compound

Product 1

HCID 67882225HCID 67882225, compound

Procedure

A solution of 0.2 g of (R)-1-O-(4-chloro-butyryl)-2-O-(methylcarbamoyl)-3-O-octadecylglycerine in 10 ml of pyridine is heated to 80° C. for 16 hours. The solution is evaporated and the residue is treated with toluene by azeotropic distillation. The residue is recrystallized from ether. There is obtained 1-[3-[[(R)-2-[(methylcarbamoyl)oxy]-3-(octadecyloxy)propoxy]carbonyl]-propyl]pyridinium chloride of melting point 53°-60° C. (dec.).

Workup

  1. customThe solution is evaporated
  2. additionthe residue is treated with toluene by azeotropic distillation
  3. customThe residue is recrystallized from ether

Sources & evidence

ORD record
ord-33220f2b74dc4edf847145f6a511c911
Source dataset
uspto-grants-1993_02
Patent number
US05187293

Reaction notes

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