Pyridine → HCID 67882256, compound

HRID 2082180Notes

Reaction equation

HRID 2082180 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([O:7][CH2:8][C@@H:9]([CH2:15][O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[O:10][C:11]([O:13][CH3:14])=[O:12])=[O:6].[N:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[Cl-:1].[CH3:14][O:13][C:11]([O:10][C@H:9]([CH2:15][O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH2:8][O:7][C:5]([NH:4][CH2:3][CH2:2][N+:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:6])=[O:12]

Participants

3

Reactant 2

HCID 1049PyridineHCID 18612286HCID 18612286, compound

Product 1

HCID 67882256HCID 67882256, compound

Procedure

A solution of 0.07 g of (R)-1-O-[(2-chloroethyl) carbamoyl]-2-O-(methoxycarbonyl)-3-O-octadecylglycerine in 10 ml of pyridine is heated at 80° C. for 3 days. The solution is evaporated and the residue is recrystallized from acetone-n-hexane. There is obtained 1-[2-[1-[(R)-2-[(methoxycarbonyl)oxy]-3-(octadecyloxy)propoxy]formamido]-ethyl]pyridinium chloride of melting point 83° C. (dec.).

Workup

  1. customThe solution is evaporated
  2. customthe residue is recrystallized from acetone-n-hexane

Sources & evidence

ORD record
ord-d88ffcfd71bf4788b0ffed09bd3d9eb7
Source dataset
uspto-grants-1993_02
Patent number
US05187293

Reaction notes

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