HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzoic Acid → Benzoic acid, 4-hydroxy-, 2-methylbutyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzoic Acid | HCID 135 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | (S)-2-methyl-1-butanol | HCID 2723602 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Benzoic acid, 4-hydroxy-, 2-methylbutyl ester | HCID 13530949 | 88.1% |
Reaction Steps
0.29 mole (40.0 g) of 4-hydroxybenzoic acid and 0.35 mole (30.9 g) of (S)-(-)-2-methylbutanol were refluxed for 20 hours in 150 ml of toluene in the presence of 1 ml of conc. sulfuric acid. The reaction solution was concentrated, and then purified by column chromatography to obtain 53.2 g of 4-hydroxybenzoic acid 2-methylbutyl ester [[α]D23 =+4.95* (CHCL3)]. (yield: 88%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05187298 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-03f04eab193a45299a09aacfd575a4ce |
| Source note | uspto-grants-1993_02 |