Chloroform → 13149-04-7

Participants

Reaction Conditions

Reaction Steps

A solution of 25 g of trans-4-cyclohexene-1,2-dicarboxylic acid diethyl ester in 140 ml of tetrahydrofuran is instilled in a suspension of 10 g of lithium aluminum hydride in 140 ml of tetrahydrofuran at room temperature and the mixture is then stirred for 3 hours at reflux temperature. It is cooled to 0° C., a mixture of tetrahydrofuran/water (1+1) is instilled slowly, stirred for 30 minutes, mixed with 150 ml of chloroform, filtered and the filtrate is concentrated by evaporation in a vacuum. The residue is distilled at 0.2 mm/Hg and at 150° C. in a bulb tube. In this way, 20 g of trans-1,6-dihydroxymethyl-3-cyclohexene is obtained as a colorless oil.

Provenance & Evidence