Water → p-Toluenesulfonic acid

Participants

Reaction Steps

A mixture of H-Phe-OH (1.65 g), 4-chlorobenzyl alcohol (7.12 g) and p-toluenesulfonic acid monohydrate (2.09 g) in carbon tetrachloride (30 ml) was refluxed for 22 hours while water was removed by molecular sieves 3Al/8. After adding diethyl ether, the white crystal was filtered, washed with diethyl ether and dried to give TsOH.H-Phe-OBzl(Cl) (4.59 g).

Provenance & Evidence