HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131717770, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N-((1,1-dimethylethoxy)carbonyl)-beta-alanine | HCID 76809 | — |
| Reactant | HCID 101632290 | HCID 101632290 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131717770 | HCID 131717770 | 87.1% |
Reaction Steps
Boc-βAla-OH (0.19 g), HCl.H-Thr-D-Trp(CHO)-Phe-NMeBzl (0.62 g) and HOBT (0.14 g) were dissolved in DMF (10 ml). To this solution was added WSC (0.18 ml) under ice cooling and the mixture was stirred for four hours at room temperature. After evaporation and extraction with ethyl acetate, the organic layer was washed successively with water, 2% sodium hydrogencarbonate solution, water, 2% hydrochloric acid, water and saturated sodium chloride solution, and dried over magnesium sulfate. The evaporated residue was crystallized from a mixed solvent of ethanol and water. Filtration and drying gave Boc-βAla-Thr-D-Trp(CHO)-Phe-NMeBzl (0.66 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05187156 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-c75147878f5a40b9b15c5dd481cc41e0 |
| Source note | uspto-grants-1993_02 |