Hydrochloric Acid → HCID 131717777, compound

Participants

Reaction Steps

To a solution of HCl.H-Gln-D-Trp(CHO)-Phe-OBzl (0.33 g) and sodium formate (0.35 g) in formic acid (21 ml) was added dropwise Ac2O (7 ml) under ice-cooling. The mixture was stirred for three and half an hour at room temperature. Water (10 ml) was added to the mixture and then evaporated. To the residue, water was added and evaporated. The residue was pulverized with water, filtered. The solids were dissolved in DMF and reprecipitated with ethyl acetate, filtered and dried to give HCO-Gln-D-Trp(CHO)-Phe-OBzl (0.27 g).

Provenance & Evidence