Sodium Methoxide → 2-Amino-4-methoxy-6-trifluoromethoxy-1,3,5-triazine

HRID 2082260Notes

Reaction equation

HRID 2082260 reaction equation
[CH3:1][O-:2].[Na+].[NH2:4][C:5]1[N:10]=[C:9](F)[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1>CO>[NH2:4][C:5]1[N:10]=[C:9]([O:2][CH3:1])[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 150103882-Amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazin

Product 1

HCID 150103932-Amino-4-methoxy-6-trifluoromethoxy-1,3,5-triazine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

9.1 g (0.05 mol) of 30% strength sodium methylate were added to a mixture of 10 g (0.05 mol) of 2-amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazine in 100 ml of methanol at 0° C. in the course of 15 minutes, while stirring. Stirring was carried out for one hour at 0° C., after which the mixture was evaporated down under reduced pressure, the residue was taken up in methylene chloride and the solution was extracted with water. Drying and evaporation gave 10.5 g (99% of theory) of the title compound of melting point 96°-101° C.

Workup

  1. stirringStirring
  2. customafter which the mixture was evaporated down under reduced pressure
  3. extractionthe solution was extracted with water
  4. customDrying
  5. customevaporation

Sources & evidence

ORD record
ord-dcc5f08acd7c4b03b0f1ab6c70a67e12
Source dataset
uspto-grants-1993_02
Patent number
US05188657

Reaction notes

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