Ethanol → HCID 67783752, compound

Participants

Reaction Steps

1.2 g (0.047 mol) of 97% strength sodium hydride were added a little at a time to 150 ml of ethanol at from 20 to 35° C. and stirring was carried out until dissolution occurred, which took 15 minutes. 10.0 g (0.047 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoro-1,3,5-triazine were then added at 0° C., while stirring, and stirring was continued for 1 hour at 0° C. and overnight at 22° C. The solution was evaporated down under reduced pressure, after which the residue was taken up in methylene chloride and the solution was extracted with water and dried. Evaporation gave 10.6 g (94.6% of theory) of the title compound of melting point 63°-65° C.

Provenance & Evidence