Tetrabutylammonium Fluoride → HCID 178444314, compound

Participants

Reaction Steps

110 ml of 1 molar solution of tetrabutylammonium fluoride in dichloromethane are added at 0° C. to a solution of 28.85 g (0.1 mol) of 1-(2-chloroethynyl)-4-(trans-4-pentylcyclohexyl)benzene in 150 ml of dichloromethane. The reaction mixture is boiled for 24 hours and evaporated in vacuo, and the residue is then extracted with 3×150 ml of petroleum ether (30°-50° C.). The combined petroleum ether phases are dried over magnesium sulphate and evaporated. The product is obtained from the resultant residue by chromatography using petroleum ether as eluent.

Provenance & Evidence