Phthalic Anhydride → Phthalic Acid

Participants

Reaction Steps

Phthalamic acids have also been prepared by addition of a solution of secondary fatty amines in isopropanol at about 78° C. to a phthalic anhydride/isopropanol slurry in a 1:1 phthalic anhydride/amine molar ratio with subsequent vacuum stripping of the solvent. This method utilizes isopropanol as the solvent for the reaction. Isopropanol, a secondary alcohol, reacts with phthalic anhydride to yield the isopropyl mono ester of phthalic acid. At 78° C., as much as 40% of the product may be an ester.

Provenance & Evidence