HCID 19777972, compound → HCID 19777992, compound

Participants

Reaction Steps

A mixture of methyl 4-[3-(8-chloro-10,11-dihydrodibenzo[b,f][1,4]oxazepin-10-yl)prop-1-ynyl]benzoate (2.7 g), 10% palladium-on-charcoal catalyst (0.05 g) and THF (100 ml) was stirred under an atmosphere of hydrogen for 9 hours. The mixture was filtered and the filtrate was evaporated. The residue was purified by column chromatography using a 9:1 v/v mixture of methylene chloride and petroleum ether (b.p. 60°-80° C.) as eluent. There were thus obtained in turn methyl 4-[3-(8-chloro-10,11-dihydrodibenzo[b,f][1,4]oxazepin-10-yl)propyl]benzoate (0.6 g) as a gum and methyl 4-[3-(10,11-dihydrodibenzo[b,f][1,4]oxazepin-10-yl)propyl]benzoate (0.18 g) as a gum.

Provenance & Evidence