HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Cyanide → (+/-)3-(Dimethylamino)tetrahydro-3-furancarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | 3-Oxotetrahydrofuran | HCID 529392 | — |
| Reactant | 1-(Dimethylamino)cyclopentanecarbonitrile | HCID 10773049 | — |
| Solvent | Water | HCID 962 | — |
| Product | (+/-)3-(Dimethylamino)tetrahydro-3-furancarbonitrile | HCID 10630582 | 88% |
Reaction Steps
The title compound (6.54 g, 88%) was prepared from dihydro-3(2H)-furanone D44 (4.54 g, 0.053 mol), dimethylamine hydrochloride (4.9 g, 0.06 mol) and potassium cyanide (3.5 g, 0.054 mol) in water (100 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 2.15 (1H, m), 2.33 (6H, s), 2.44 (1H, m), 3.69 (1H, d), 4.02-4.13 (2H, m), 4.17 (1H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745642B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-016a263677f94642b1a0aff980bd059e |
| Source note | uspto-grants-2010_06 |