2-Chloro-4,6-dimethylpyrimidine → HCID 19778088, compound

Participants

Reaction Steps

A mixture of 0.255 g (1.00 mmol) of 1,3-dimethyl-4-(4-chlorophenylthio)-5-hydroxypyrazole and 0.43 g (3.00 mmol) of 2-chloro-4,6-dimethylpyrimidine was heated on a bath of which temperature was 130° C. for 3 hours with stirring. After completing the reaction, the reaction mixture was purified by means of silica gel column chromatography (developing solution: ethyl acetate) to give 0.308 g of 1,3-dimethyl-4-(4-chlorophenylthio)-5-(4,6-dimethylpyrimidine-2-yloxy)pyrazole.

Provenance & Evidence