2-Fluoropyridine → HCID 19778082, compound

Participants

Reaction Steps

A mixture of 0.5 g (2 mmol) of 1,3-dimethyl-4-(2-chlorophenylthio)-5-hydroxypyrazole and 0.97 g (10 mmol) of 2-fluoropyridine was refluxed with heating for 8 hours. After completing the reaction, the reaction mixture was purified by means of silica gel column chromatography (developing solution: ethyl acetate-hexane (3:2 v/v)) to give 0.17 g of 1,3-dimethyl-4-(2-chlorophenylthio)-5-(pyridine-2-yloxy)pyrazole.

Provenance & Evidence