1-(4-fluorobenzoyl)piperidine-4-carboxylic acid → HCID 19778040, compound

HRID 2082307Notes

Reaction equation

HRID 2082307 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]([OH:16])=O)[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[CH3:19][Mg]Br>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]2[CH2:9][CH2:10][CH:11]([C:14](=[O:16])[CH3:19])[CH2:12][CH2:13]2)=[O:7])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 7780751-(4-fluorobenzoyl)piperidine-4-carboxylic acidHCID 178418573HCID 178418573, compound

Product 1

HCID 19778040HCID 19778040, compound

Procedure

In a manner similar to that described in Preparation 4, 1-(4-fluorobenzoyl)piperidine-4-carboxylic acid is reacted with methylmagnesium bromide to afford the title compound.

Sources & evidence

ORD record
ord-46bf7ffa5ec2415394868cd8c11138a7
Source dataset
uspto-grants-1993_02
Patent number
US05189036

Reaction notes

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