Butyl isocyanate → HCID 3976331, compound

HRID 2082310Notes

Reaction equation

HRID 2082310 reaction equation
[CH2:1]([N:5]=[C:6]=[O:7])[CH2:2][CH2:3][CH3:4].[C:8]1([CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH2:21])[CH2:17][CH2:16]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(Cl)Cl>[CH2:1]([NH:5][C:6]([NH:21][CH:18]1[CH2:19][CH2:20][N:15]([CH2:14][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:16][CH2:17]1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 8110Butyl isocyanateHCID 4158521-Benzyl-4-piperidylamine

Product 1

HCID 3976331HCID 3976331, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Butyl isocyanate (33.9 g, 342 mmol) is added dropwise to a solution of 1-(phenylmethyl)-4-piperidinamine (65 g, 342 mmol) in methylene chloride (400 mL) at 0° C., and the mixture is stirred for 2 hr. The mixture is washed three times with water, dried over magnesium sulfate, and evaporated. Recrystallization of the residue from methylene chloride-hexane affords the title compound.

Workup

  1. washThe mixture is washed three times with water
  2. dry with materialdried over magnesium sulfate
  3. customevaporated
  4. customRecrystallization of the residue from methylene chloride-hexane

Sources & evidence

ORD record
ord-0f23eb5eed1a43629b97ad17cac166c7
Source dataset
uspto-grants-1993_02
Patent number
US05189036

Reaction notes

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