Phosgene → 1-Chloroformyl-6,7,8,9-tetrahydropyrido[1,2-a]indole

Participants

Reaction Steps

The methyl ester of Formula III wherein Z is --N(R2)-- and R1 and R2 are together --(CH2)3 --, namely methyl 6,7,8,9-tetrahydropyrido[1,2-a]indole-2-carboxylate, is prepared by reacting 6,7,8,9-tetrahydropyrido[1,2-a]indole with phosgene to form 1-chloroformyl-6,7,8,9-tetrahydropyrido[1,2-a]indole and subsequently converting this product to the methyl ester. A more detailed description of this procedure is set forth in Example 1 of this application. The 6,7,8,9-tetrahydropyrido[1,2-a]indole may be prepared via an intramolecular Wittig reaction (M. D. Crenshaw and H. Zimmer, J. Heterocyclic Chem., (1984) 21, 623).

Provenance & Evidence