m-Chloroperbenzoic acid → HCID 86746563, compound

Participants

Reaction Conditions

Reaction Steps

m-Chloroperoxybenzoic acid (1.2 g, 7.0 mmol) was added in small portions at 0° C. to a solution of (S)-2-(1-azabicyclo[2.2.2]oct-3-yl)1,2-dihydro-5-methyl-1-oxopyrido[4,3-b]indole (1.8 g, 5.8 mmol), from Example 3, in dichloromethane (50 mL). The reaction mixture was stirred for additional 0.5 hour at 0° C. The solvent was removed under reduced pressure and the residue was purified by column chromatography (10% methanol in dichloromethane and 1% ammonium hydroxide) to afford 0.75 g (62% yield) of (S)-2-(1-azabicyclo[2.2.2]oct-3-yl)-1,2-dihydro-5-methyl-1-oxopyrido[4,3-b]indole N-oxide, as an amorphous solid, m.p 98°-102° C.

Provenance & Evidence