Acetylethanolamine → HCID 178474919, compound

Participants

Reaction Steps

To a solution of 0.31 g (1.5 mmol) of 1,3-dicyclohexylcarbodiimide in tetrahydrofuran (3 ml) is added 0.28 g (1.5 mmol) of 3-phenylpropylphosphinic acid in tetrahydrofuran (1 ml). The resulting suspension is stirred for 10 minutes at room temperature. N-acetyl ethanolamine (0.10 g, 1.0 mol) is then added, followed by 18 mg or 4-dimethylaminopyridine. The mixture is stirred for 2 hours. The solvent is evaporated under reduced pressure, and the residue is stirred with ethyl acetate (20 ml). The resulting suspension is filtered. The filtrate is washed with 5% potassium hydrogen sulfate (8 ml), saturated sodium bicarbonate (2×5 ml), and brine (5 ml), and evaporated to give 0.12 g of a colorless oil.

Provenance & Evidence