Propylamine → HCID 19778147, compound

Participants

Reaction Steps

Ethyl 4-bromocrotonate (21.4 g) was added dropwise to a solution of n-propylamine (11.8 g) and triethylamine (20.2 g) in ethanol (80 ml) at 0° C. under stirring and taking 1.5 hours, followed by stirring for 0.5 hours at room temperature. After removing the solvent, to the residue was added ethyl acetate, and the mixture was extracted with 1N hydrochloric acid. The extract was alkalified with potassium carbonate powder and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulfate and distilled to remove the solvent to give 13.5 of the title compound as pale yellow oily substance.

Provenance & Evidence