Sodium Hydroxide → HCID 19778135, compound

Participants

Reaction Steps

1N-Sodium hydroxide (3 ml) was added to a solution of the compound (500 mg) obtained by Step 6 in methanol (25 ml) at room temperature under stirring. The mixture was stirred at room temperature for 1.5 hours and then the solvent was distilled off. The residue to which water was added was washed with ethyl acetate. The aqueous layer was acidified with aqueous potassium hydrogen sulfate solution and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulfate and distilled to give the title compound (410 mg) as colorless crystals. mp 207°-209° C. (from methanol-diethyl ether).

Provenance & Evidence