HCID 15445561, compound → 139004-92-5

Participants

Reaction Conditions

Reaction Steps

To a solution of 230 mL (0.23 mmol) of 1M lithium aluminum hydride in THF was added over 20 min a solution of (S)-N-benzylpiperidine-2-carboxamide in 150 mL of THF. The mixture was refluxed for 5 h, diluted with 500 ml of THF, cooled to -78° C. and quenched with a solution of 48 mL 1N aqueous sodium hydroxide in 200 mL THF. The resulting slurry was filtered through a Celite® pad and concentrated at reduced pressure to yield (S)-N-benzyl-2-aminomethylpiperidine (10.9 g, 89%).

Provenance & Evidence