HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoroaniline → 2-[(2-Fluorophenyl)amino]nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoroaniline | HCID 9584 | — |
| Reactant | 2-Chloronicotinic acid | HCID 76258 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 2-[(2-Fluorophenyl)amino]nicotinic acid | HCID 2393555 | — |
Reaction Steps
50 g of 2-chloronicotinic acid and 31 ml of 2-fluoroaniline in 180 ml of xylene are refluxed for 5 hours. The precipitate is filtered off and washed with xylene and then with water to yield the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05189045 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-798f6fe6fc054c2da83683a25000b2e4 |
| Source note | uspto-grants-1993_02 |