2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester → HCID 13561847, compound

HRID 2082387Notes

Reaction equation

HRID 2082387 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][NH2:14].[C:15]([C:17](=[CH:23]OCC)[C:18]([O:20][CH2:21][CH3:22])=[O:19])#[N:16]>C(O)C>[NH2:16][C:15]1[N:13]([C:3]2[C:2]([Cl:1])=[CH:7][C:6]([C:8]([F:9])([F:11])[F:10])=[CH:5][C:4]=2[Cl:12])[N:14]=[CH:23][C:17]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19]

Participants

4

Reactant 2

HCID 789432-Propenoic acid, 2-cyano-3-ethoxy-, ethyl esterHCID 688223[2,6-Dichloro-4-(trifluoromethyl)phenyl]hydrazine

Product 1

HCID 13561847HCID 13561847, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2,6-dichloro-4-trifluoromethylphenylhydrazine (10 g) and ethyl 2-cyano-3-ethoxyacrylate (7.0 g) in absolute ethanol (200 ml) was heated under reflux with stirring for 24 hours. Evaporation of solvent and recrystallisation from diisopropyl ether gave ethyl 5-amino-l-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazole-4-carboxylate, m.p. 131°-134°.

Workup

  1. temperatureunder reflux
  2. customEvaporation of solvent and recrystallisation from diisopropyl ether

Sources & evidence

ORD record
ord-92d9b2b44f4d43f49c84b26e4948f1c3
Source dataset
uspto-grants-1993_02
Patent number
US05189053

Reaction notes

Loading…