HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 2-(2,6-dichloro-4-trifluoromethylphenyl)-4-[(4,5-dicyano-1H-imidazol-2-ylamino)-methyl]-2H-1,2,3-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1H-Imidazole-4,5-dicarbonitrile, 2-amino- | HCID 170446 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 2-(2,6-Dichloro-4-trifluoromethylphenyl)-1,2,3-triazole-4-carboxaldehyde | HCID 19778308 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(2,6-dichloro-4-trifluoromethylphenyl)-4-[(4,5-dicyano-1H-imidazol-2-ylamino)-methyl]-2H-1,2,3-triazole | HCID 19778373 | — |
Reaction Steps
Sodium cyanoborohydride (0.05 g) was added to a solution of 2-(2,6-dichloro-4-trifluoromethylphenyl)-1,2,3-triazole-4-carboxaldehyde (0.3 g), potassium hydroxide (0.04 g) and 2-amino-4,5-dicyanoimidazole (0.3 g) in methanol (20 ml). After 20 hours at room temperature, the solvent was evaporated under reduced pressure and the residue purified by silica gel chromatography to give 2-(2,6-dichloro-4-trifluoromethylphenyl)-4-[(4,5-dicyano-1H-imidazol-2-ylamino)methyl]-2H-1,2,3-triazole, m.p. 213°-215°. (Compound 25)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05189053 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-2afe987297da4962a91c7698201b24ea |
| Source note | uspto-grants-1993_02 |