Ethyl Acetoacetate → HCID 178472852, compound

Participants

Reaction Steps

A solution of sodium nitrite (45 g) in concentrated sulphuric acid (340 ml) was added to a solution of 2,6-dichloro-4-trifluoromethylaniline (140 g) in glacial acetic acid (550 ml) while maintaining the temperature below 25°. The mixture was stirred at room temperature for one hour, and was added quite rapidly to a stirred mixture of ethyl acetoacetate (80 g), sodium acetate (180 g), ethanol (300 ml) and ice-water (3 l ). After 1 hour, the brown solid was filtered and dried to give ethyl 2-(2,6-dichloro-4-trifluoromethylphenylhydrazono)-3-oxobutyrate.

Provenance & Evidence