Phosphorous acid → HCID 19778367, compound

HRID 2082397Notes

Reaction equation

HRID 2082397 reaction equation
N[C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[CH:4][C:3]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20].P(O)(O)O>>[Cl:13][C:12]1[CH:11]=[C:10]([C:14]([F:17])([F:15])[F:16])[CH:9]=[C:8]([Cl:18])[C:7]=1[N:6]1[CH:2]=[C:3]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:4]=[N:5]1

Participants

3

Reactant 2

HCID 107909Phosphorous acidHCID 13561847HCID 13561847, compound

Product 1

HCID 19778367HCID 19778367, compound

Procedure

Ethyl 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazole-4-carboxylate, was diazotised and treated with phosphorous acid to give ethyl 1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazole-4-carboxylate, m.p. 70°-73°. This was reduced to [1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazol-4-yl]methanol, m.p. 57°-59°

Sources & evidence

ORD record
ord-c3eb387e3bbe49859e574dbbbcf033c7
Source dataset
uspto-grants-1993_02
Patent number
US05189053

Reaction notes

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