Glyoxylic Acid → HCID 11023864, compound

HRID 2082477Notes

Reaction equation

HRID 2082477 reaction equation
[CH2:1]([C:3]1[C:8]([NH2:9])=[C:7]([CH3:10])[CH:6]=[CH:5][CH:4]=1)[CH3:2].[C:11]([OH:15])(=[O:14])[CH:12]=O>CO>[NH2:9][C:8]1[C:3]([CH2:1][CH3:2])=[CH:4][C:5]([CH:12]([C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[C:8]([NH2:9])=[C:7]([CH3:10])[CH:6]=2)[C:11]([OH:15])=[O:14])=[CH:6][C:7]=1[CH3:10]

Participants

4

Reactant 2

HCID 760Glyoxylic AcidHCID 324852-Ethyl-6-methylaniline

Product 1

HCID 11023864HCID 11023864, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 6-ethyl-2-methylaniline (30.0 parts) and methanol (100 parts) was stirred at ambient temperature. Glyoxylic acid 50% w/v (16.5 parts) was added and the mixture was stirred for 24 hours at ambient temperature. The precipitated product was isolated by filtration, washed with methanol (20 parts) and dried to yield di(4-amino-5-ethyl-3-methylphenyl)acetic acid (31.0 parts).

Workup

  1. additionwas added
  2. stirringthe mixture was stirred for 24 hours at ambient temperature
  3. customThe precipitated product was isolated by filtration
  4. washwashed with methanol (20 parts)
  5. customdried

Sources & evidence

ORD record
ord-25a9ab156da04657a6cc4f20edf329da
Source dataset
uspto-grants-1993_02
Patent number
US05189181

Reaction notes

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