HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2082482Generated: October 31, 2026
Lithium hydroxide, monohydrate → HCID 21460787, compound
https://huagongshe.com/reaction/2082482
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | HCID 21460728 | HCID 21460728 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Solvent | Water ethylacetate | HCID 22728543 | — |
| Product | HCID 21460787 | HCID 21460787 | 50% |
Reaction Steps
Dissolve 3-[(2-acetoxyphenacyl)amino]-2-carbmethoxy-6-chloroindole (800 mg, 2.15 mmol) in tetrahydrofuran/water (20 mL, 1/1). Add lithium hydroxide monohydrate (932 mg, 8.5 mmol). Seal the flask and warm to 60° C. for 3 hours. Dilute with ethyl acetate/water, acidify and separate the organic phase. Dry, precipitate with hexane and filter the solid to give the title compound (358 mg, 50%); mp 198°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05189054 |
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| Source dataset | uspto-grants-1993_02 |
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| ORD ID | ord-eb9bfd6dce8c4c8f8e4ff4002afed3b5 |
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| Source note | uspto-grants-1993_02 |
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