Hydrochloric Acid → HCID 21460700, compound

Participants

Reaction Steps

Mix 3-[(p-fluorophenacyl)amino)-2-carbethoxy-4,6-dichloroindole (600 mg, 1.52 mmol) , lithium hydroxide (191 mg, 4.55 mmol), tetrahydrofuran (20 mL) and water (20 mL). Stir overnight at room temperature. Dilute with water (20 mL) and ethyl acetate (40 mL). Acidify with 1N HCl while stirring and separate the layers. Dry the organic phase over magnesium sulfate, filter and concentrate in vacuo. Recrystallize the residue (ethyl acetate/hexane) to yield the title compound as a white powder (440 mg, 79%); mp 259°-261° C.

Provenance & Evidence