Sodium Bicarbonate → HCID 21460702, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 3-[(4-nitrophenacyl)amino]-2-carbethoxy-4,6-dichloroindole (0.5 g, 1.184 mmol) in ethanol (20 mL) and tin (II) chloride monohydrate (1.06 g, 7.1 mmol). Heat to 70° C. overnight. Pour into ethyl acetate/water (200 mL) and add solid sodium hydrogen carbonate to obtain pH 7. Filter and evaporate the solvent in vacuo to give the title compound as a pale yellow oil (0.477, 100%).

Provenance & Evidence