Sodium Hydroxide → HCID 10454998, compound

Participants

Reaction Steps

To a mixture of ethyl 4-[2-(4-chlorophenylsulfonylamino)ethylthio]-2,6-difluorophenoxyacetate (0.46 g) and tetrahydrofuran (30 ml) was added under ice cooling lithium aluminum hydride (38 mg), and the mixture was stirred at room temperature for an hour. To the reaction mixture was added successively 10% aqueous sodium hydroxide solution (0.2 ml), ethyl acetate (30 ml) and anhydrous sodium sulfate (1 g), and the insolubles were removed by filtration. After evaporation of the filtrate under reduced pressure, the residue was chromatographed on silica gel column (ethyl acetate:hexane=1:1), and the desired fractions were collected and recrystallized from ethyl ether/isopropyl ether mixture to give 2-{4-[2-(4-chlorophenylsulfonylamino)ethylthio]-2,6-difluorophenoxy}ethanol (Compound No. 129).

Provenance & Evidence