Ammonia → HCID 10094588, compound

HRID 2082579Notes

Reaction equation

HRID 2082579 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][S:14][C:15]2[CH:26]=[C:25]([F:27])[C:18]([O:19][CH2:20][C:21](OC)=[O:22])=[C:17]([F:28])[CH:16]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH3:29]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][S:14][C:15]2[CH:26]=[C:25]([F:27])[C:18]([O:19][CH2:20][C:21]([NH2:29])=[O:22])=[C:17]([F:28])[CH:16]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 10433987HCID 10433987, compound

Product 1

HCID 10094588HCID 10094588, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 4-[2-(4-chlorophenylsulfonylamino)ethylthio]-2,6-difluorophenoxyacetate (1 g) was added to methanol (50 ml) saturated with ammonia gas, and the mixture was allowed to stand at room temperature for 3 days. The reaction mixture was evaporated under reduced pressure, and the residue was recrystallized from methanol to give 4-[2-(4-chlorophenylsulfonylamino)ethylthio]-2,6-difluorophenoxyacetamide (Compound No. 132).

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. customthe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-b4d40ac50a7c4f4f8216ebdbd4d42a94
Source dataset
uspto-grants-1993_02
Patent number
US05189211

Reaction notes

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