Acetic Acid → HCID 57075633, compound

Participants

Reaction Steps

A solution of 17-ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-azido-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-14,18-diene-2, 3,10,16-tetraone (55 mg), tetrakistriphenylphosphine palladium (10 mg), and acetic acid (10 μl) in 3 ml of dry toluene is stirred for 5 min at room temperature under nitrogen atmosphere. To this yellow solution is added tributyltin hydride (30 μl) and stirred an additional 45 min at room temperature. The reaction mixture is subjected to column chromatography on silica gel (elute first with hexane and then with 50% ethyl acetate/hexane) to give the title compound.

Provenance & Evidence