Methyl iodide → HCID 57075633, compound

Participants

Reaction Steps

A suspension of 17-ethyl-20-fluoro-1-hydroxy-12-[2'-(4"-azido-3"-hydroxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone (20 mg) and silver oxide (20 mg) in 1.5 ml of methyl iodide is refluxed in a gas-tight bottle for 4 days. The yellow solid is filtered off and the excess methyl iodide is removed. Purification of crude material by preparative tlc on silica gel gives the title compound.

Provenance & Evidence