HCID 57276360, compound → HCID 57207245, compound

Participants

Reaction Steps

To a solution of 17-ethyl-20-fluoro-1-hydroxy-14-(tert-butyldimethylsiloxy)-12-[2'-(4"-(2-benzyloxyethoxy)-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16tetraone (10 mg) in acetonitrile (500 μl) is added a solution of 2% HF in aqueous acetonitrile (200 μl), and the mixture is stirred at room temperature. After 2.5 hours, the solution is diluted with ethyl acetate, extracted with saturated sodium bicarbonate solution and the organic phase dried over magnesium sulfate. Purification of the concentrate by flash chromatography on silica gel gives the title compound.

Provenance & Evidence