反应详情

To 1-hydroxy-6-chloro-2-(trifluoromethyl)-1H-Imidazo(4,5-b)pyridine (2.37 grams) in 5 milliliters of pyridine was added octanoyl chloride (1.63 grams). The addition was carried out portionwise with stirring and resulted in the precipitation of a white solid. The reaction mixture was set on a steam bath for twenty minutes, then poured over ice cold aqueous HCl. An oil separated and subsequently crystallized on vigorous stirring. This precipitate was removed by filtration, dissolved in ether, dried over magnesium sulfate, filtered, and ether removed by evaporation under vacuum. The substance was purified by distillation, m.p., 33.5°-35.5° C.

1. additionThe addition
2. customresulted in the precipitation of a white solid
3. waitThe reaction mixture was set on a steam bath for twenty minutes
4. additionpoured over ice cold aqueous HCl
5. customAn oil separated
6. customsubsequently crystallized on vigorous stirring
7. customThis precipitate was removed by filtration
8. dissolutiondissolved in ether
9. dry with materialdried over magnesium sulfate
10. filtrationfiltered
11. customether removed by evaporation under vacuum
12. distillationThe substance was purified by distillation
13. customm.p., 33.5°-35.5° C.