Sodium Hydroxide → Maltol

HRID 2082661Notes

Reaction equation

HRID 2082661 reaction equation
CO[CH:3]1[O:8][CH:7]([CH3:9])[C:6](=[O:10])[CH:5]=[CH:4]1.ClCl.[OH-:13].[Na+]>C(O)(=O)C.O>[CH3:9][C:7]1[O:8][CH:3]=[CH:4][C:5](=[O:13])[C:6]=1[OH:10]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 24526ChlorineHCID 130117926-Methoxy-2-methyl-2H-pyran-3(6H)-one

Product 1

HCID 8369Maltol

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

A solution of 6-methoxy-2-methyl-2H-pyran-3(6H)-one (0.01 mole) in 20 ml of acetic acid as treated with gaseous chlorine (0.01 mole) at room temperature. The reaction mixture was then heated to reflux for about one hour, cooled to room temperature, diluted with 20 ml of water, the pH adjusted with 50% NaOH solution to 7.0 and the reaction mixture extracted with chloroform. The chloroform extract was concentrated to yield maltol which was recrystallized from methanol to give pure product (56%), mp 159.5°-160.5° C.

Workup

  1. temperatureThe reaction mixture was then heated
  2. temperatureto reflux for about one hour
  3. extractionthe reaction mixture extracted with chloroform
  4. extractionThe chloroform extract
  5. concentrationwas concentrated

Sources & evidence

ORD record
ord-8a28204f82834559a85b66052f639505
Source dataset
uspto-grants-1978_04
Patent number
US04082717

Reaction notes

Loading…