Ethanolamine → HCID 20360357, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 70 parts of 1-(chlorophenylmethyl)-3-(trifluoromethyl)benzene and 250 parts of 2-aminoethanol is stirred for 3 hours at 140° C. The reaction mixture is cooled and poured onto water. The product is extracted with 4-methyl-2-pentanone. The extract is dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and methanol (95:5 by volume) as eluent. The pure fractions are collected and the eluent is evaporated, yielding 60 parts (82%) of 2-[{phenyl[3-(trifluoromethyl)phenyl]methyl}amino]ethanol as a residue.

Provenance & Evidence