Thionyl Chloride → HCID 20360379, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred and cooled (5°-10° C) mixture of 60 parts of 2-[{phenyl[3-(trifluoromethyl)phenyl]methyl}amino]-ethanol and 540 parts of methylbenzene are added dropwise 40 parts of sulfinyl chloride. Upon completion, stirring is continued first till room temperature is reached and further overnight at reflux temperature. The reaction mixture is concentrated to one third its volume. After cooling to 10° C, the solid product is filtered off, washed with 2,2'-oxybispropane and dried in vacuo at 75° C, yielding 28.5 parts (40%) of N-(2-chloroethyl)-α-phenyl-3-(trifluoromethyl)benzenemethanamine hydrochloride; mp. 187° C.

Provenance & Evidence