HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → HCID 20360377, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(4-Fluorophenyl)-1,3,8-triazaspiro(4.5)decan-4-one | HCID 93915 | — |
| Reactant | N-[Bis(4-fluorophenyl)methyl]-2-chloroethan-1-amine--hydrogen chloride (1/1) | HCID 3017749 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | HCID 20360377 | HCID 20360377 | — |
Reaction Steps
A mixture of 8 parts of N-(2-chloroethyl)-4-fluoro-α-(4-fluorophenyl)benzenemethanamine hydrochloride, 5.7 parts of 1-(4-fluorophenyl)-1,3,8-triazaspiro[4,5]decan-4-one, 10 parts of sodium carbonate, 0.1 parts of potassium iodide and 80 parts of 4-methyl-2-pentanone is stirred and refluxed overnight. The reaction mixture is taken up in water and after stirring for a while, the precipitated product is filtered off. The product is washed with 4-methyl-2-pentanone, dried and crystallized from 4-methyl-2-pentanone (activated charcoal). It is filtered off and dried, yielding 4 parts of 8-[2-{[bis(4-fluorophenyl)methyl]amino}ethyl]-1-(4-fluorophenyl)-1,3,8-triazaspiro[4,5]decan-4-one; mp. 193° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04082755 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-e57139be2a0b40d883432f90d9007e3a |
| Source note | uspto-grants-1978_04 |