HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → benzyl L-alanyl-D-isoglutaminate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Boc-ala-D-glu(obzl)-NH2 | HCID 7289350 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | benzyl L-alanyl-D-isoglutaminate hydrochloride | HCID 12873810 | — |
Reaction Steps
To 0.406 g of benzyl t-butyloxycarbonyl-L-alanyl-D-isoglutaminate (7, n = 2, X1 = L-alanyl) at 22° C there is added 5 ml of a saturated solution of hydrogen chloride in ethyl acetate. After 10 minutes, 40 ml of ether is added and the precipitated salt is collected by centrifugation and carefully dried in vacuo to give 0.325 g of benzyl L-alanyl-D-isoglutaminate hydrochloride (10, n = 2, X1 = L-alanyl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04082735 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-e708dae2c93d4254aa82133d0860208f |
| Source note | uspto-grants-1978_04 |