Imidazole → L-Methionine
Reaction equation
[CH3:1][S:2][CH2:3][CH2:4][CH:5]1[NH:9]C(=O)N[C:6]1=[O:11].N1C=CN=C1.[OH2:17]>>[NH2:9][C@H:5]([C:6]([OH:11])=[O:17])[CH2:4][CH2:3][S:2][CH3:1]Participants
4
Procedure
A mixture of 1.74 g. of 5-(β-methylthioethyl)hydantoin, 68 mg. of imidazole and 20 ml. of water was heated to 160° C. in a 50 ml. autoclave, and was allowed to react at 160° C. for 6 hours. After the reaction was over, the autoclave was rapidly cooled. The reaction mixture was treated by the same after-treatment as in Example 1 and methionine was obtained in yield of 80%.
Workup
- additionA mixture of 1.74 g
- customto react at 160° C. for 6 hours
- temperaturewas rapidly cooled
- additionThe reaction mixture was treated by the same after-treatment as in Example 1
Sources & evidence
- ORD record
- ord-9c39a9bb15ad40a3be9ad62ccbfa63bd
- Source dataset
- uspto-grants-1978_04
- Patent number
- US04082767
Reaction notes
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